Biswajit Pradhan
Notebook of

Biswajit Pradhan

Biophysicist · single-molecule imaging · scientific software

Max Planck Institute of Biophysics, Frankfurt

Hey there! I'm Biswajit, and I'm fascinated by the tiny details that make life tick. At the Max Planck Institute of Biophysics I study how DNA is organised, by watching single motor proteins fold it into loops. My background is a bit of a mix: I've built microscopes, delved into the world of single molecules, and written code to make sense of the data.

Here you'll find my research, the apps and projects I build, occasional notes and my CV. I'm always up for collaborating, so feel free to reach out.

Portrait of Biswajit Pradhan
Fig. 1A kymograph: position along a tethered DNA (vertical) over time (horizontal). The bright, thickening traces are DNA loops being extruded. Drawn at build time.
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Projects & apps

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science · active · 2026 · web app

KymoScope

Kymograph analysis for single-molecule DNA experiments, rebuilt in Rust. One engine drives a desktop app, a browser app, a command line and Python.

  • rust
  • webassembly
  • single-molecule
  • image analysis
▶ Run
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Selected publications

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  1. Loop-extrusion-mediated plasmid DNA cleavage by the bacterial SMC Wadjet complex

    Biswajit Pradhan, Amar Deep, Jessica König, Martin D. Baaske, Kevin D. Corbett, Eugene Kim

    Molecular Cell 85(1), 107–116 (2025)

  2. Loop-extruding Smc5/6 organizes transcription-induced positive DNA supercoils

    Kristian Jeppsson, Biswajit Pradhan, Takashi Sutani, Toyonori Sakata, Miki Umeda Igarashi, Davide Giorgio Berta, Takaharu Kanno, Ryuichiro Nakato, Katsuhiko Shirahige, Eugene Kim, et al.

    Molecular Cell 84(5), 867–882 (2024) · cover article

  3. Symmetry of loop extrusion by dimeric SMC complexes is DNA-tension-dependent

    Biswajit Pradhan, Adrian Pinto, Takaharu Kanno, Damla Tetiker, Martin D. Baaske, Erin Cutt, Constantinos Chatzicharlampous, Herwig Schüler, Amar Deep, Kevin D. Corbett, et al.

    bioRxiv (2024)preprint

  4. The Smc5/6 complex is a DNA loop-extruding motor

    Biswajit Pradhan, Takaharu Kanno, Miki Umeda Igarashi, Mun Siong Loke, Martin Dieter Baaske, Jan Siu Kei Wong, Kristian Jeppsson, Camilla Björkegren, Eugene Kim

    Nature 616, 843–848 (2023)

  5. Condensin-driven loop extrusion on supercoiled DNA

    Eugene Kim, Alejandro Martin Gonzalez, Biswajit Pradhan, Jaco van der Torre, Cees Dekker

    Nature Structural & Molecular Biology 29(7), 719–727 (2022)

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Recent notes

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